Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.43 |
| ▸ | SLC6A12 | P48065 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | GABRP | O00591 | 2/20 | 0.36 |
| ▸ | GABRD | O14764 | 2/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.36 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.36 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.36 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.36 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.36 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.36 |
| ▸ | GABRA4 | P48169 | 2/20 | 0.36 |
| ▸ | GABRE | P78334 | 2/20 | 0.36 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.36 |
| ▸ | GABRG1 | Q8N1C3 | 2/20 | 0.36 |
| ▸ | GABRG3 | Q99928 | 2/20 | 0.36 |
| ▸ | GABRQ | Q9UN88 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10031554 | 0.83 | EGFR (0.47) | HSP90AB1POLBGABRPGABRDGABRA1 | |
| SCHEMBL27785442 | 0.83 | HSP90AB1 (0.42) | HSP90AB1POLBGABRPGABRDGABRA1 | |
| SCHEMBL16533890 | 0.81 | HSP90AB1 (0.41) | HSP90AB1POLBGABRPGABRDGABRA1 | |
| SCHEMBL27510077 | 0.81 | SLC6A12 (0.38) | SLC6A12ALDH1A1KMT2AKDM4EMAPT | |
| SCHEMBL26803352 | 0.80 | SLC6A12 (0.39) | SLC6A12ALDH1A1TUBB4ATUBBTUBA3C | |
| SCHEMBL1568399 | 0.79 | SLC6A12 (0.43) | SLC6A12POLBKMT2AMAPTTUBB4A | |
| SCHEMBL2082473 | 0.79 | PKM (0.43) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL29980368 | 0.79 | PKM (0.43) | ALDH1A1KMT2AKDM4EMEN1SMN1; SMN2 | |
| SCHEMBL30436565 | 0.78 | SMN1; SMN2 (0.40) | SLC6A12GABRPGABRDGABRA1GABRB1 | |
| SCHEMBL3702546 | 0.78 | SMN1; SMN2 (0.40) | SLC6A12GABRPGABRDGABRA1GABRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1956957-A | Method for the production of a-chloroalkylpyridyl ketones and/or the hydrochlorides thereof | BASF AG (DE) | 2007-05-02 | — | — | CN | claimed |
| WO-2018234353-A1 | NOVEL SUBSTITUTED INDOLE AND INDAZOLE COMPOUNDS AS PHOSPHODIESTERASE INHIBITORS | Grünenthal GmbH (DE) | 2018-12-27 | — | — | WO | disclosed |
| CN-1956957-A | Method for the production of a-chloroalkylpyridyl ketones and/or the hydrochlorides thereof | BASF AG (DE) | 2007-05-02 | — | — | CN | disclosed |
| US-5821255-A | REGULATING THE SECRETION OF CORTICOTROPIN, BETA-ENDORPHIN OR PEPTIDES DERIVED FROM PROOPIOMELANOCORTIN | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| EP-0659747-B1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-04-01 | — | — | EP | disclosed |
| US-5602132-A | USEFUL IN TREATMENT OF PATHOLOGIES INVOLVING CORTICOTROPIN RELEASING FACTOR | SANOFI (FR) | 1997-02-11 | — | — | US | disclosed |
| CN-1127252-A | Branched-amino-sbustituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them | SANOFI SA (FR) | 1996-07-24 | — | — | CN | disclosed |
| EP-0659747-A1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-06-28 | — | — | EP | disclosed |