Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.47 |
| ▸ | KDR | P35968 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.47 |
| ▸ | GAK | O14976 | 3/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.46 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.46 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.46 |
| ▸ | TXK | P42681 | 1/20 | 0.46 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.46 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.45 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.45 |
| ▸ | STK16 | O75716 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | BMP2K | Q9NSY1 | 1/20 | 0.45 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31510479 | 1.00 | CCNC (0.48) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL31312344 | 0.86 | ADRB2 (0.51) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL9829215 | 0.86 | ADRB2 (0.51) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL26029318 | 0.82 | RIPK2 (0.47) | RIPK2KDRMAPK14GAKNLK | |
| SCHEMBL16248020 | 0.80 | CCNC (0.49) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL317086 | 0.79 | CCNC (0.48) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL16289500 | 0.79 | CCNC (0.48) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL422643 | 0.79 | SMN1; SMN2 (0.59) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL30050271 | 0.79 | CCNC (0.48) | CCNCCDK8RIPK2KDRMAPK14 | |
| SCHEMBL4421437 | 0.79 | RIPK2 (0.53) | CCNCCDK8RIPK2KDRMAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696291-B1 | PYRIDO(1,2,3-DE)QUINOXALINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND THEIR USE IN MEDICAMENTS | SCHERING AG (DE) | 1998-08-19 | — | — | EP | disclosed |
| US-5750526-A | Pyrido 1,2,3-DE!quinoxaline derivatives, process for their production and their use in pharmaceutical agents | SCHERING AKTIENGESELLSCHAFT (DE) | 1998-05-12 | — | — | US | disclosed |
| CN-1121720-A | Pyrido(1,2,3-de)quinoxaline derivatives, process for preparing the same and their use in medicaments | SCHERING AG (DE) | 1996-05-01 | — | — | CN | disclosed |
| EP-0696291-A1 | PYRIDO(1,2,3-DE)QUINOXALINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025472-A1 | PYRIDO(1,2,3-DE)QUINOXALINE DERIVATIVES, PROCESS FOR PREPARING THE SAME AND THEIR USE IN MEDICAMENTS | SCHERING AKTIENGESELLSCHAFT (DE) | 1994-11-10 | — | — | WO | disclosed |