Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 15/20 | 0.56 |
| ▸ | DRD4 | P21917 | 12/20 | 0.56 |
| ▸ | DRD3 | P35462 | 11/20 | 0.56 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.44 |
| ▸ | KCNJ1 | P48048 | 2/20 | 0.44 |
| ▸ | HTR2A | P28223 | 2/20 | 0.44 |
| ▸ | HTR2C | P28335 | 2/20 | 0.44 |
| ▸ | HTR2B | P41595 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | PRCP | P42785 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547917 | 0.86 | USP30 (0.41) | DRD2DRD4DRD3USP30KCNH2 | |
| SCHEMBL8548112 | 0.85 | DRD4 (0.59) | DRD2DRD4DRD3KCNH2HTR2A | |
| SCHEMBL14665852 | 0.81 | PRCP (0.51) | DRD2DRD4DRD3HTR2AHTR2C | |
| SCHEMBL14686654 | 0.81 | DRD2 (0.52) | DRD2DRD4DRD3KCNH2KCNJ1 | |
| SCHEMBL8547614 | 0.80 | SIGMAR1 (0.55) | DRD2DRD4DRD3KCNH2KCNJ1 | |
| SCHEMBL1388360 | 0.80 | DRD4 (0.70) | DRD2DRD4DRD3PRCP | |
| SCHEMBL8550958 | 0.77 | DRD2 (0.41) | DRD2DRD4DRD3USP30KCNH2 | |
| SCHEMBL1388548 | 0.77 | DRD4 (0.69) | DRD2DRD4DRD3PRCP | |
| SCHEMBL1388551 | 0.76 | DRD4 (0.70) | DRD2DRD4DRD3HTR2ASIGMAR1 | |
| SCHEMBL7948408 | 0.75 | HTR2A (0.75) | DRD2DRD4DRD3KCNH2HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | claimed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | claimed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | claimed |
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| US-5668148-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |