Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.43 |
| ▸ | EDNRA | P25101 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.36 |
| ▸ | PDE4A | P27815 | 2/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.34 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.34 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.34 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547955 | 0.92 | EDNRB (0.43) | EDNRBEDNRAPDE4BPDE4APDE4C | |
| SCHEMBL8547597 | 0.89 | EDNRB (0.47) | EDNRBEDNRAPDE4BPDE4APDE4C | |
| SCHEMBL8552935 | 0.87 | EDNRB (0.60) | EDNRBEDNRAMAPT | |
| SCHEMBL8547128 | 0.86 | EDNRB (0.49) | EDNRBEDNRAPDE4BPDE4APDE4C | |
| SCHEMBL8551818 | 0.84 | EDNRB (0.41) | EDNRBEDNRAABL1MAPTMAPK1 | |
| SCHEMBL8552678 | 0.84 | EDNRB (0.43) | EDNRBEDNRAABL1MAPTMAPK1 | |
| SCHEMBL8552610 | 0.83 | EDNRB (0.46) | EDNRBEDNRAMAPT | |
| SCHEMBL8550952 | 0.83 | EDNRB (0.46) | EDNRBEDNRAPDE4BPDE4APDE4C | |
| SCHEMBL8547749 | 0.83 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL8552487 | 0.83 | EDNRB (0.44) | EDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |