Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.46 |
| ▸ | EDNRA | P25101 | 5/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549381 | 0.95 | EDNRB (0.43) | EDNRBEDNRAKDM4EALDH1A1GAA | |
| SCHEMBL8547955 | 0.92 | EDNRB (0.43) | EDNRBEDNRAKDM4EALDH1A1 | |
| SCHEMBL8548293 | 0.91 | EDNRB (0.45) | EDNRBEDNRAKDM4EALDH1A1GAA | |
| SCHEMBL8550986 | 0.90 | EDNRB (0.51) | EDNRBEDNRAKDM4EALDH1A1GAA | |
| SCHEMBL8548217 | 0.90 | EDNRB (0.51) | EDNRBEDNRAKDM4EALDH1A1HSD17B10 | |
| SCHEMBL8552500 | 0.90 | EDNRB (0.57) | EDNRBEDNRAKDM4EALDH1A1GAA | |
| SCHEMBL8547962 | 0.89 | EDNRB (0.43) | EDNRBEDNRAKDM4EALDH1A1GAA | |
| SCHEMBL8552639 | 0.89 | EDNRB (0.43) | EDNRBEDNRAALDH1A1GAAMAPT | |
| SCHEMBL8547935 | 0.87 | EDNRB (0.43) | EDNRBEDNRAGAAMEN1KMT2A | |
| SCHEMBL8552763 | 0.85 | EDNRB (0.47) | EDNRBEDNRAKDM4EGAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |