Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.44 |
| ▸ | EDNRA | P25101 | 4/20 | 0.44 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.35 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.34 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | PLK1 | P53350 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547749 | 0.91 | EDNRB (0.41) | EDNRBEDNRA | |
| SCHEMBL8551818 | 0.89 | EDNRB (0.41) | EDNRBEDNRAMAPT | |
| SCHEMBL8551760 | 0.85 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8551802 | 0.84 | EDNRB (0.39) | EDNRBEDNRAMAPT | |
| SCHEMBL8547858 | 0.83 | EDNRB (0.43) | EDNRBEDNRAMAPT | |
| SCHEMBL8547935 | 0.82 | EDNRB (0.43) | EDNRBEDNRATSHRTDP1 | |
| SCHEMBL8552678 | 0.82 | EDNRB (0.43) | EDNRBEDNRAMAPT | |
| SCHEMBL8550898 | 0.82 | EDNRB (0.47) | EDNRBEDNRASRD5A1SRD5A2TSHR | |
| SCHEMBL8552610 | 0.81 | EDNRB (0.46) | EDNRBEDNRAMAPT | |
| SCHEMBL8550986 | 0.81 | EDNRB (0.51) | EDNRBEDNRAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |