Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.47 |
| ▸ | EDNRA | P25101 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.33 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | MDM4 | O15151 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.31 |
| ▸ | TNF | P01375 | 1/20 | 0.31 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546234 | 0.92 | EDNRB (0.57) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8548805 | 0.91 | EDNRB (0.45) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8547872 | 0.90 | EDNRB (0.48) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8552478 | 0.89 | EDNRB (0.48) | EDNRBEDNRAKDM4EHSD17B10PLA2G2A | |
| SCHEMBL8547644 | 0.88 | EDNRB (0.45) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8547813 | 0.87 | EDNRB (0.64) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8549528 | 0.87 | EDNRB (0.45) | EDNRBEDNRAELANESMN1; SMN2MAPT | |
| SCHEMBL8550954 | 0.86 | EDNRB (0.46) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8547997 | 0.86 | EDNRB (0.54) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8547912 | 0.85 | EDNRB (0.43) | EDNRBEDNRAKDM4EGAAPLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |