Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.36 |
| ▸ | RELA | Q04206 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405147 | 0.79 | L3MBTL1 (0.50) | MAPTL3MBTL1MAPK1NPSR1KMT2A | |
| SCHEMBL4408415 | 0.79 | L3MBTL1 (0.50) | MAPTL3MBTL1MAPK1NPSR1KMT2A | |
| SCHEMBL25670058 | 0.75 | MAPT (0.53) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL25670071 | 0.74 | MAPT (0.52) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL9621838 | 0.74 | MAPT (0.54) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL8741872 | 0.73 | MAPT (0.60) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL8468455 | 0.73 | L3MBTL1 (0.47) | MAPTL3MBTL1MAPK1NPSR1KMT2A | |
| SCHEMBL10388546 | 0.73 | MAPT (0.41) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL25670064 | 0.73 | MAPT (0.50) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 | |
| SCHEMBL25670072 | 0.72 | MAPT (0.49) | MAPTL3MBTL1MAPK1NPSR1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2432760-A1 | BRIDGED SPIRO [2.4]HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | Actelion Pharmaceuticals Ltd. (CH) | 2012-03-28 | — | — | EP | disclosed |
| WO-2010134014-A1 | BRIDGED SPIRO [2.4] HEPTANE DERIVATIVES AS ALX RECEPTOR AND/OR FPRL2 AGONISTS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-11-25 | — | — | WO | disclosed |