SCHEMBL8548208

SCHEMBL8548208

C=CC(=O)OC(C)N(C)C(=O)c1ccccc1C(=O)N(C)C(C)OC(=O)C=C

nearest known ligand 0.38

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 4/20 0.38
KMT2A Q03164 4/20 0.38
TP53 P04637 2/20 0.34
TSHR P16473 3/20 0.33
ALDH1A1 P00352 3/20 0.33
THRB P10828 2/20 0.33
CYP3A4 P08684 1/20 0.33
HCAR2 Q8TDS4 1/20 0.33
SMN1; SMN2 Q16637 2/20 0.33
KEAP1 Q14145 1/20 0.33
GAA P10253 1/20 0.33
MAPT P10636 1/20 0.33
IRAK4 Q9NWZ3 1/20 0.32
HPGD P15428 2/20 0.31
THRA P10827 1/20 0.31
LMNA P02545 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8550442 0.81 TP53 (0.38) MEN1KMT2ATP53TSHRALDH1A1
SCHEMBL8547553 0.79 TP53 (0.46) TP53TSHRALDH1A1THRBCYP3A4
SCHEMBL7644507 0.74 HCAR2 (0.41) KMT2ATP53TSHRALDH1A1THRB
Phthalic Acid SCHEMBL335919 0.72 ALDH1A1 (0.48) TSHRALDH1A1CYP3A4HCAR2SMN1; SMN2
SCHEMBL301790 0.72 TSHR (0.43) KMT2ATSHRALDH1A1THRBCYP3A4
SCHEMBL1866176 0.72 TSHR (0.43) KMT2ATSHRALDH1A1THRBCYP3A4
SCHEMBL14135507 0.72 ALDH1A1 (0.41) TP53TSHRALDH1A1THRBHCAR2
SCHEMBL11456917 0.72 TSHR (0.43) TP53TSHRALDH1A1CYP3A4HCAR2
SCHEMBL15114 0.72 TSHR (0.43) TP53TSHRALDH1A1CYP3A4HCAR2
Phthalic Acid SCHEMBL301413 0.71 ALDH1A1 (0.47) MEN1KMT2ATSHRALDH1A1THRB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0724503-B1 ABRASIVE ARTICLES INCORPORATING ADDITION POLYMERIZABLE RESINS AND REACTIVE DILUENTS, AND METHODS OF MAKING SAID ABRASIVE ARTICLES MINNESOTA MINING & MFG (US) 1998-11-11 EP disclosed
US-5736747-A SOLUBLE CURING AGENTS FOR PHENOLIC RESINS OR PHOTOPOLYMERIZABLE MONOMER MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-04-07 US disclosed
US-5733648-A FOR AMINOPLASTS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-03-31 US disclosed
US-5710281-A Organic compounds suitable as reactive diluents and binder precursor compositions including same MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-01-20 US disclosed
US-5709935-A ACRYLATE FUNCTIONAL DILUENTS WHICH SOLUBILIZE AMINO RESINS MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1998-01-20 US disclosed
US-5667842-A Abrasive articles incorporating addition polymerizable resins and reactive diluents, and methods of making said abrasive articles MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1997-09-16 US disclosed
US-5580647-A OPEN NON-WOVEN MAT HAVING FIBERS JOINED AT POINTS OF CONTACT BY BINDER FROM ADDITION POLYMERIZABLE BINDER PRECURSOR MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-12-03 US disclosed
US-5523152-A Organic compounds suitable as reactive diluents, and binder precursor compositions including same MINNESOTA MINING AND MANUFACTURING COMPANY (US) 1996-06-04 US disclosed