Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1D | P25100 | 1/20 | 0.52 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.52 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.52 |
| ▸ | ADRA2C | P18825 | 6/20 | 0.49 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.49 |
| ▸ | ADRA2B | P18089 | 5/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6974323 | 1.00 | ADRA1D (0.52) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL8386689 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL8381573 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL6983083 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL6982474 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL8382544 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL6977805 | 0.92 | ADRA1D (0.50) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL8384761 | 0.90 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL6977939 | 0.90 | ADRA1D (0.49) | ADRA1DADRA1AADRA1BADRA2CADRA2A | |
| SCHEMBL6978123 | 0.85 | ADRA2A (0.58) | ADRA1DADRA1AADRA1BADRA2CADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0839145-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | Knoll AG (DE) | 1998-05-06 | — | — | EP | disclosed |
| WO-1997003071-A1 | HETEROCYCLYLCARBOXAMIDE DERIVATIVES AND THEIR USE AS THERAPEUTIC AGENTS | KNOLL AKTIENGESELLSCHAFT (DE) | 1997-01-30 | — | — | WO | disclosed |