Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN1 | Q05586 | 4/20 | 0.65 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.61 |
| ▸ | GRIN2D | O15399 | 2/20 | 0.49 |
| ▸ | GRIN3B | O60391 | 2/20 | 0.49 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.49 |
| ▸ | GRIN2C | Q14957 | 2/20 | 0.49 |
| ▸ | GRIN3A | Q8TCU5 | 2/20 | 0.49 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8543200 | 0.89 | GRIN1 (0.52) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8542536 | 0.89 | GRIN1 (0.52) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8543338 | 0.84 | GRIN1 (0.64) | GRIN1GRIN2BACHE | |
| SCHEMBL8542972 | 0.83 | GRIN2B (0.60) | GRIN1GRIN2BACHE | |
| SCHEMBL8547626 | 0.81 | GRIN1 (0.51) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL8549819 | 0.81 | GRIN2B (0.58) | GRIN1GRIN2BACHE | |
| SCHEMBL8548402 | 0.81 | GRIN1 (0.65) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL4579028 | 0.79 | ALDH1A1 (0.68) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL21061872 | 0.79 | MGLL (0.59) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A | |
| SCHEMBL30541708 | 0.79 | MGLL (0.59) | GRIN1GRIN2BGRIN2DGRIN3BGRIN2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0709384-B1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GMBH (DE) | 1998-12-23 | — | — | EP | disclosed |
| US-5698553-A | Benzylpiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-12-16 | — | — | US | disclosed |
| EP-0709384-A1 | Benzylpiperidine derivatives having high affinity for binding sites of aminoacid receptors | MERCK PATENT GmbH (DE) | 1996-05-01 | — | — | EP | disclosed |