Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.63 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8541700 | 0.89 | LMNA (0.64) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL8543224 | 0.83 | LMNA (0.65) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL8550744 | 0.75 | NPC1 (0.48) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL9699303 | 0.74 | LMNA (0.54) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL25443048 | 0.74 | NPC1 (0.53) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL9699296 | 0.73 | LMNA (0.52) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| Oxalic Acid SCHEMBL9190729 | 0.72 | NPC1 (0.49) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL5915332 | 0.72 | SMN1; SMN2 (0.80) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL12339968 | 0.68 | NPC1 (0.65) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 | |
| SCHEMBL5915307 | 0.68 | LMNA (0.78) | LMNASMN1; SMN2NPC1ALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0614893-B1 | Benzoxazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1998-05-27 | — | — | EP | disclosed |
| US-5447928-A | Antiischemic agents and nervous system disorders | SYNTHELABO (FR) | 1995-09-05 | — | — | US | disclosed |
| EP-0614893-A1 | Benzoazine derivatives, their preparation and their use in therapy | SYNTHELABO (FR) | 1994-09-14 | — | — | EP | disclosed |