Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.38 |
| ▸ | NOS1 | P29475 | 2/20 | 0.38 |
| ▸ | NOS2 | P35228 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293625 | 0.75 | — | — | |
| SCHEMBL9228942 | 0.74 | KDM4E (0.35) | — | |
| SCHEMBL28326283 | 0.71 | — | — | |
| SCHEMBL17318344 | 0.71 | KEAP1 (0.39) | NOS3NOS1NOS2 | |
| SCHEMBL3962816 | 0.70 | EPHX1 (0.53) | — | |
| SCHEMBL15496325 | 0.70 | — | — | |
| SCHEMBL5837947 | 0.70 | — | — | |
| SCHEMBL5799232 | 0.69 | NOS3 (0.44) | NOS3NOS1NOS2 | |
| SCHEMBL11361936 | 0.68 | — | — | |
| SCHEMBL15683024 | 0.67 | DRD4 (0.49) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |