SCHEMBL8548740

SCHEMBL8548740

COC(=O)c1cccc(NC(=O)CCCCBr)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.69
CYP1A2 P05177 1/20 0.69
CYP3A4 P08684 1/20 0.69
CYP2D6 P10635 1/20 0.69
CYP2C9 P11712 1/20 0.69
CYP2C19 P33261 1/20 0.69
HPGD P15428 1/20 0.66
MEN1 O00255 2/20 0.61
KMT2A Q03164 2/20 0.61
LMNA P02545 2/20 0.59
HIF1A Q16665 3/20 0.57
MDH1 P40925 3/20 0.57
MDH2 P40926 2/20 0.57
RAB9A P51151 3/20 0.57
HTT P42858 1/20 0.55
NPC1 O15118 1/20 0.55
PARP1 P09874 1/20 0.54
PARP10 Q53GL7 1/20 0.54
TP53 P04637 1/20 0.52
SMN1; SMN2 Q16637 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21998681 0.88 ALDH1A1 (0.67) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL21998673 0.88 ALDH1A1 (0.67) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL21998663 0.88 ALDH1A1 (0.67) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL7575475 0.87 ALDH1A1 (0.70) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL131787 0.85 ALDH1A1 (0.64) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5853506 0.82 KDM4E (0.53) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL5999793 0.81 HDAC1 (0.65) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL9030520 0.81 L3MBTL1 (0.68) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL24027984 0.80 ALDH1A1 (0.64) ALDH1A1CYP1A2CYP3A4CYP2D6CYP2C9
SCHEMBL21805191 0.80 GAA (0.62) ALDH1A1CYP3A4HPGDMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0715624-B1 PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMA CO LTD (JP) 1998-04-08 EP disclosed
US-5728829-A MULTISTAGE REACTION OF N-PROTECTED BENZOTRIAZOLYL GLYCINE DERIVATIVE WITH AMINOKETONE, THEN REACTION WITH AMMONIA AND ACID CATALYZED CYCLIZATION FERRING-RESEARCH LIMITED (GB) 1998-03-17 US disclosed
EP-0715624-A1 PROCESS FOR THE PREPARATION OF BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-06-12 EP disclosed
WO-1995006040-A1 BENZODIAZEPINE COMPOUNDS USEFUL AS ANTAGONISTS OF CCK OR OF GASTRINE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1995-03-02 WO disclosed