SCHEMBL8548889

SCHEMBL8548889

COc1cc(Oc2ccc(C=O)cc2)cc(Oc2ccc(C=O)cc2)c1

nearest known ligand 0.69

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 6/20 0.69
CYP2A6 P11509 1/20 0.69
ESR1 P03372 4/20 0.52
TTR P02766 2/20 0.52
CYP1A1 P04798 2/20 0.52
CYP1B1 Q16678 2/20 0.52
NQO2 P16083 2/20 0.52
CYP1A2 P05177 2/20 0.52
AHR P35869 2/20 0.52
ABL1 P00519 1/20 0.52
ABCB1 P08183 1/20 0.52
ALOX5 P09917 1/20 0.52
BCR P11274 1/20 0.52
CYP19A1 P11511 1/20 0.52
PTGS2 P35354 1/20 0.52
TUBB4A P04350 1/20 0.52
TUBB P07437 1/20 0.52
TUBA3C P0DPH7 1/20 0.52
TUBA1B P68363 1/20 0.52
TUBA4A P68366 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL527049 0.90 ALDH1A1 (0.86) ALDH1A1CYP2A6TTRCYP1A2PARP10
SCHEMBL30644968 0.87 ALDH1A1 (0.62) ALDH1A1CYP2A6TTRLMNAKDM4E
SCHEMBL1874850 0.87 ALDH1A1 (0.62) ALDH1A1CYP2A6TTRLMNAKDM4E
SCHEMBL3970350 0.84 ALDH1A1 (0.50) ALDH1A1CYP2A6ESR1TTRCYP1A1
SCHEMBL8547510 0.84 ALDH1A1 (0.53) ALDH1A1CYP2A6TTRPARP10PARP3
Anisaldehyde SCHEMBL717471 0.83 ALDH1A1 (1.00) ALDH1A1CYP2A6ESR1TTRCYP1A1
Anisaldehyde SCHEMBL1100 0.83 ALDH1A1 (1.00) ALDH1A1CYP2A6ESR1TTRCYP1A1
SCHEMBL1663469 0.82 PARP10 (0.65) ALDH1A1CYP2A6PARP10PARP3LMNA
SCHEMBL5050902 0.82 PARP10 (0.65) ALDH1A1CYP2A6PARP10PARP3LMNA
SCHEMBL19296413 0.82 ALDH1A1 (0.55) ALDH1A1CYP2A6TTRCYP1A1CYP1B1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed