Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTB4R2 | Q9NPC1 | 5/20 | 0.41 |
| ▸ | BDKRB1 | P46663 | 3/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 4/20 | 0.38 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.36 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8944237 | 0.75 | LTB4R2 (0.62) | LTB4R2AGTR1 | |
| SCHEMBL8944228 | 0.68 | KDM4E (0.42) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL13356516 | 0.63 | LTB4R2 (0.54) | LTB4R2BDKRB1SLC6A3SLC6A4AGTR1 | |
| SCHEMBL8553480 | 0.63 | LTB4R2 (0.53) | LTB4R2BDKRB1AGTR1AGTR2 | |
| SCHEMBL30480719 | 0.62 | KDM4E (0.56) | SLC6A3SLC6A4ALDH1A1KMT2AKDM4E | |
| SCHEMBL9140079 | 0.61 | LTB4R2 (0.52) | LTB4R2BDKRB1SLC6A3SLC6A4ACHE | |
| SCHEMBL9808846 | 0.61 | LTB4R2 (0.60) | LTB4R2BDKRB1SLC6A3SLC6A4ACHE | |
| SCHEMBL29979869 | 0.60 | SLC6A3 (0.69) | LTB4R2BDKRB1SLC6A3SLC6A4ACHE | |
| SCHEMBL14326964 | 0.60 | SLC6A3 (0.69) | LTB4R2BDKRB1SLC6A3SLC6A4ACHE | |
| SCHEMBL3126983 | 0.60 | LTB4R2 (0.79) | LTB4R2AGTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |