SCHEMBL8549227

SCHEMBL8549227

c1ccc(-c2cc(-c3ccco3)nc(-c3ccco3)c2)cc1

nearest known ligand 0.70

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MYC P01106 5/20 0.70
PIK3R1 P27986 1/20 0.54
PIK3CA P42336 1/20 0.54
SMARCA2 P51531 1/20 0.54
PBRM1 Q86U86 1/20 0.54
ADORA2A P29274 3/20 0.54
ADORA1 P30542 3/20 0.54
ADORA2B P29275 2/20 0.54
KDM4E B2RXH2 5/20 0.50
ALDH1A1 P00352 4/20 0.50
HPGD P15428 4/20 0.50
HSD17B10 Q99714 4/20 0.50
POLB P06746 4/20 0.50
MEN1 O00255 3/20 0.50
KMT2A Q03164 3/20 0.50
TDP1 Q9NUW8 3/20 0.50
L3MBTL1 Q9Y468 3/20 0.50
USP2 O75604 2/20 0.50
ABCB1 P08183 1/20 0.50
TOP1 P11387 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL14805206 0.85 MYC (0.59) MYCPIK3R1PIK3CAADORA2AADORA1
SCHEMBL28398408 0.84 MYC (0.54) MYCPIK3R1PIK3CASMARCA2PBRM1
SCHEMBL18044782 0.82 MYC (0.77) MYCADORA2AKDM4EALDH1A1HPGD
SCHEMBL8623836 0.80 MYC (0.53) MYCADORA2AKDM4EALDH1A1HSD17B10
SCHEMBL13458910 0.79 SMARCA2 (0.52) MYCPIK3R1PIK3CASMARCA2PBRM1
SCHEMBL24689626 0.78 LMNA (0.51) MYCPIK3R1PIK3CASMARCA2PBRM1
SCHEMBL11183265 0.76 MYC (0.50) MYCADORA2AADORA1ADORA2BKDM4E
SCHEMBL7404185 0.74 TAAR1 (0.64) MYCPIK3R1PIK3CASMARCA2PBRM1
SCHEMBL3060017 0.74 KDM4E (0.58) PIK3R1PIK3CAADORA2AADORA1KDM4E
SCHEMBL960513 0.74 CYP19A1 (0.65) MYCADORA2AADORA1ADORA2BALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0525825-B1 Substituted dicarboxy pyridine compounds EG & G WALLAC OY (FI) 1998-12-09 EP disclosed
EP-0272320-B1 HOMOGENEOUS FLUOROASSAY METHODS EMPLOYING FLUORESCENT BACKGROUND REJECTION BAXTER DIAGNOSTICS INC (US) 1994-03-23 EP disclosed
EP-0195413-B1 Substituted pyridine derivatives BAXTER DIAGNOSTICS INC (US) 1993-11-18 EP disclosed
EP-0525825-A2 Substituted dicarboxy pyridine compounds Dade MicroScan Inc. (US) 1993-02-03 EP disclosed
EP-0272320-A4 HOMOGENEOUS FLUOROASSAY METHODS EMPLOYING FLUORESCENT BACKGROUND REJECTION. BAXTER TRAVENOL LAB (US) 1989-08-09 EP disclosed
US-4761481-A FLUORESCENT CHELATES, AMINE ACID COMPOUNDS BAXTER TRAVENOL LABORATORIES, INC. (US) 1988-08-02 US disclosed
EP-0272320-A1 HOMOGENEOUS FLUOROASSAY METHODS EMPLOYING FLUORESCENT BACKGROUND REJECTION. BAXTER TRAVENOL LAB (US) 1988-06-29 EP disclosed
WO-1987007955-A1 HOMOGENEOUS FLUOROASSAY METHODS EMPLOYING FLUORESCENT BACKGROUND REJECTION AND WATER-SOLUBLE RARE EARTH METAL CHELATE FLUOROPHORES BAXTER TRAVENOL LABORATORIES, INC. (US) 1987-12-30 WO disclosed
EP-0195413-A2 Substituted pyridine derivatives Baxter Diagnostics Inc. (US) 1986-09-24 EP disclosed