Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 7/20 | 0.47 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 6/20 | 0.47 |
| ▸ | DRD3 | P35462 | 6/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | RAD52 | P43351 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.40 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8709640 | 0.89 | DRD2 (0.53) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8707306 | 0.88 | DRD2 (0.52) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8548017 | 0.86 | DRD2 (0.50) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8548067 | 0.83 | KMT2A (0.41) | DRD2SLC6A4HTR2ADRD3MAPK1 | |
| SCHEMBL8549309 | 0.83 | UBE2M (0.39) | DRD2SLC6A4 | |
| SCHEMBL8552345 | 0.82 | DRD2 (0.54) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8548019 | 0.82 | DRD2 (0.49) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8548871 | 0.82 | DRD2 (0.41) | DRD2SLC6A4HTR2ADRD3RAB9A | |
| SCHEMBL8703719 | 0.81 | DRD2 (0.53) | DRD2SLC6A4HTR2ADRD3 | |
| SCHEMBL8550206 | 0.81 | DRD2 (0.47) | DRD2SLC6A4MAPK1POLBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |