Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.53 |
| ▸ | EDNRA | P25101 | 12/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.39 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.39 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546724 | 0.93 | EDNRB (0.57) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8552424 | 0.89 | EDNRB (0.43) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8551203 | 0.88 | EDNRB (0.52) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8548322 | 0.87 | EDNRB (0.42) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8552497 | 0.87 | EDNRB (0.43) | EDNRBEDNRAKDM4EMEN1KMT2A | |
| SCHEMBL8546719 | 0.86 | EDNRB (0.69) | EDNRBEDNRA | |
| SCHEMBL8549630 | 0.86 | EDNRB (0.52) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8551101 | 0.83 | EDNRB (0.53) | EDNRBEDNRAKDM4ELMNAMAPT | |
| SCHEMBL8547997 | 0.82 | EDNRB (0.54) | EDNRBEDNRAKDM4EMEN1PPARG | |
| SCHEMBL8548088 | 0.81 | EDNRB (0.47) | EDNRBEDNRAKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |