Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.43 |
| ▸ | EDNRA | P25101 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | KIT | P10721 | 3/20 | 0.35 |
| ▸ | SERPINE1 | P05121 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | PPARA | Q07869 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551203 | 0.93 | EDNRB (0.52) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8548322 | 0.92 | EDNRB (0.42) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8548088 | 0.92 | EDNRB (0.47) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8552497 | 0.91 | EDNRB (0.43) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8549321 | 0.89 | EDNRB (0.53) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8547644 | 0.87 | EDNRB (0.45) | EDNRBEDNRAKDM4EHSD17B10LMNA | |
| SCHEMBL8550954 | 0.86 | EDNRB (0.46) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8548086 | 0.85 | EDNRB (0.58) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8551102 | 0.84 | EDNRB (0.45) | EDNRBEDNRAHPGDALDH1A1KDM4E | |
| SCHEMBL8549337 | 0.83 | EDNRB (0.47) | EDNRBEDNRAHPGDALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |