Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 6/20 | 0.43 |
| ▸ | EDNRA | P25101 | 3/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BCHE | P06276 | 1/20 | 0.33 |
| ▸ | ACHE | P22303 | 1/20 | 0.33 |
| ▸ | SERPINE1 | P05121 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | HTT | P42858 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551203 | 0.92 | EDNRB (0.52) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8546571 | 0.92 | EDNRB (0.47) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8552424 | 0.91 | EDNRB (0.43) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8548322 | 0.89 | EDNRB (0.42) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8547512 | 0.88 | EDNRB (0.46) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8549321 | 0.87 | EDNRB (0.53) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8547254 | 0.87 | EDNRB (0.46) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8546569 | 0.87 | EDNRB (0.59) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8547872 | 0.84 | EDNRB (0.48) | EDNRBEDNRAALDH1A1HPGDKDM4E | |
| SCHEMBL8548088 | 0.83 | EDNRB (0.47) | EDNRBEDNRAALDH1A1HPGDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |