Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 3/20 | 0.45 |
| ▸ | EDNRA | P25101 | 2/20 | 0.40 |
| ▸ | AR | P10275 | 1/20 | 0.38 |
| ▸ | ELANE | P08246 | 1/20 | 0.37 |
| ▸ | TXNRD1 | Q16881 | 1/20 | 0.37 |
| ▸ | TXNRD3 | Q86VQ6 | 1/20 | 0.37 |
| ▸ | TXNRD2 | Q9NNW7 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.37 |
| ▸ | F2RL3 | Q96RI0 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8548809 | 0.92 | EDNRB (0.54) | EDNRBEDNRAELANE | |
| SCHEMBL8552742 | 0.92 | EDNRB (0.43) | EDNRBEDNRAARELANETXNRD1 | |
| SCHEMBL8552520 | 0.90 | EDNRB (0.46) | EDNRBEDNRAELANE | |
| SCHEMBL8552494 | 0.88 | EDNRB (0.49) | EDNRBEDNRAELANE | |
| SCHEMBL8549337 | 0.87 | EDNRB (0.47) | EDNRBEDNRAELANEMAPTSMN1; SMN2 | |
| SCHEMBL8546118 | 0.85 | EDNRB (0.42) | EDNRBEDNRAELANEMEN1KMT2A | |
| SCHEMBL8547644 | 0.85 | EDNRB (0.45) | EDNRBEDNRAELANEMEN1KMT2A | |
| SCHEMBL8547813 | 0.84 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8548911 | 0.84 | EDNRB (0.46) | EDNRBEDNRAELANEMAPTLMNA | |
| SCHEMBL8550954 | 0.84 | EDNRB (0.46) | EDNRBEDNRAMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |