Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.39 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | CCR2 | P41597 | 2/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | HTR3A | P46098 | 1/20 | 0.37 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8708757 | 0.93 | DRD2 (0.53) | DRD2SLC6A4BCHE | |
| SCHEMBL8550206 | 0.86 | DRD2 (0.47) | DRD2SLC6A4 | |
| SCHEMBL8702974 | 0.86 | DRD2 (0.53) | DRD2SLC6A4BCHECCR2KCNH2 | |
| SCHEMBL8549396 | 0.85 | DRD2 (0.49) | DRD2SLC6A4BCHEKCNH2HTR1A | |
| SCHEMBL8551116 | 0.84 | DRD2 (0.47) | DRD2SLC6A4 | |
| SCHEMBL8703019 | 0.84 | DRD2 (0.53) | DRD2SLC6A4BCHECCR2 | |
| SCHEMBL7484437 | 0.82 | HTR1D (0.55) | DRD2CCR2HTR1A | |
| SCHEMBL8548017 | 0.82 | DRD2 (0.50) | DRD2SLC6A4DRD3 | |
| SCHEMBL8706839 | 0.81 | DRD2 (0.48) | DRD2SLC6A4CHRM3CCR2KCNH2 | |
| SCHEMBL8704937 | 0.81 | DRD2 (0.44) | DRD2SLC6A4KCNH2HTR1ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |