Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.38 |
| ▸ | UBE2M | P61081 | 9/20 | 0.37 |
| ▸ | DCUN1D1 | Q96GG9 | 9/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | DRD1 | P21728 | 1/20 | 0.36 |
| ▸ | DRD4 | P21917 | 1/20 | 0.36 |
| ▸ | DRD5 | P21918 | 1/20 | 0.36 |
| ▸ | DRD3 | P35462 | 1/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | HTR1D | P28221 | 1/20 | 0.35 |
| ▸ | HTR1B | P28222 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549392 | 0.85 | DRD2 (0.50) | DRD2SLC6A4BCHEKCNH2HTR1A | |
| SCHEMBL8708757 | 0.85 | DRD2 (0.53) | DRD2SLC6A4BCHEUBE2MDCUN1D1 | |
| SCHEMBL8702974 | 0.84 | DRD2 (0.53) | DRD2SLC6A4BCHEUBE2MDCUN1D1 | |
| SCHEMBL8547064 | 0.83 | DRD2 (0.46) | DRD2SLC6A4BCHEUBE2MDCUN1D1 | |
| SCHEMBL8551607 | 0.83 | DRD2 (0.57) | DRD2SLC6A4UBE2MDCUN1D1 | |
| SCHEMBL8548019 | 0.83 | DRD2 (0.49) | DRD2SLC6A4DRD3 | |
| SCHEMBL7484443 | 0.83 | HTR1D (0.54) | DRD2HTR1ACHRM2HTR1DHTR1B | |
| SCHEMBL8550206 | 0.82 | DRD2 (0.47) | DRD2SLC6A4CHRM2HTR1DHTR1B | |
| SCHEMBL8547257 | 0.82 | DRD2 (0.48) | DRD2SLC6A4BCHEUBE2MDCUN1D1 | |
| SCHEMBL8703019 | 0.81 | DRD2 (0.53) | DRD2SLC6A4BCHEUBE2MDCUN1D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |