Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOA | P21397 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TYMS | P04818 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.40 |
| ▸ | CES1 | P23141 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.36 |
| ▸ | MMP3 | P08254 | 1/20 | 0.36 |
| ▸ | MMP9 | P14780 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.36 |
| ▸ | HTR2C | P28335 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13151881 | 0.78 | MAOA (0.32) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL9273526 | 0.76 | PBRM1 (0.41) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL8791015 | 0.76 | PBRM1 (0.41) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL32672790 | 0.75 | TDP2 (0.50) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL855553 | 0.75 | MAOA (0.47) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL1611599 | 0.75 | MAOA (0.47) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL855947 | 0.75 | MAOB (0.47) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL31616856 | 0.75 | KDM4E (0.47) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL4455687 | 0.75 | KDM4E (0.47) | MAOAMAOBKDM4EALDH1A1TYMS | |
| SCHEMBL29838115 | 0.75 | MAOA (0.47) | MAOAMAOBKDM4EALDH1A1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022204150-A1 | COMPOUNDS AND COMPOSITIONS FOR TREATING CNS DISORDERS | BLUE OAK PHARMACEUTICALS, INC. (US) | 2022-09-29 | — | — | WO | disclosed |
| US-9309250-B2 | Substituted pyrrolo[2,3-b]pyrazines as ATR kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2016-04-12 | — | — | US | disclosed |
| CN-102046580-B | Methods for preparing oxydiphthalic anhydrides | SABIC INNOVATIVE PLASTICS IP | 2015-02-04 | — | — | CN | disclosed |
| EP-2723746-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | Vertex Pharmaceuticals Inc. (US) | 2014-04-30 | — | — | EP | disclosed |
| US-8604221-B2 | Production method of halogen-substituted phthalide | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2013-12-10 | — | — | US | disclosed |
| EP-2271611-B1 | METHOD FOR PREPARING 4,4'-OXYDIPHTHALIC ANHYDRIDE | SABIC INNOVATIVE PLASTICS IP (NL) | 2013-09-04 | — | — | EP | disclosed |
| US-20130034616-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2013-02-07 | — | — | US | disclosed |
| WO-2012178125-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-12-27 | — | — | WO | disclosed |
| US-20120142946-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2012-06-07 | — | — | US | disclosed |
| EP-2433933-A1 | PRODUCTION METHOD OF HALOGEN-SUBSTITUTED PHTHALIDE | Sumitomo Chemical Company, Limited (JP) | 2012-03-28 | — | — | EP | disclosed |
| EP-1390339-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | Syngenta Participations AG (CH) | 2004-02-25 | — | — | EP | disclosed |
| EP-1375468-A2 | Method for removing impurities from oxidation products | GENERAL ELECTRIC COMPANY (US) | 2004-01-02 | — | — | EP | disclosed |
| US-6670487-B1 | Of ortho-dimethylbenzene compounds; phthalic acid and phthalic anhydride by oxidation of ortho-xylene; extracting solution of aromatic anhydride product with an aqueous bicarbonate to hydrolyze the anhydride to the acid | GENERAL ELECTRIC COMPANY | 2003-12-30 | — | — | US | disclosed |
| WO-2002094760-A2 | PROCESS FOR THE PREPARATION OF 7-SUBSTITUTED 3-ALKYL-3H-ISOBENZOFURAN-1-ONE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2002-11-28 | — | — | WO | disclosed |
| EP-0461079-B1 | Substituted phthalides and heterocyclic phthalides | CIBA GEIGY AG (CH) | 1997-07-16 | — | — | EP | disclosed |
| US-5627138-A | HERBICIDES | SANDOZ LTD. (CH) | 1997-05-06 | — | — | US | disclosed |
| US-5627137-A | HERBICIDES | SANDOZ LTD. (CH) | 1997-05-06 | — | — | US | disclosed |
| US-5561101-A | HERBICIDES | SANDOZ LTD. (CH) | 1996-10-01 | — | — | US | disclosed |
| US-5506192-A | HERBICIDES | SANDOZ LTD. | 1996-04-09 | — | — | US | disclosed |
| EP-0461079-A2 | Substituted phthalides and heterocyclic phthalides | SANDOZ LTD. (CH) | 1991-12-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20130034616-A1 | COMPOUNDS USEFUL AS INHIBITORS OF ATR KINASE | ATR, CHEK1, MAP3K5 | MAOA 3499/4885MAOB 3227/4885KDM4E 1959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.