SCHEMBL8549986

SCHEMBL8549986

O=Cc1ccc(Oc2ccc(Cl)c(Oc3ccc(C=O)cc3)c2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.47
PARP10 Q53GL7 1/20 0.46
PARP3 Q9Y6F1 1/20 0.46
KDM4E B2RXH2 2/20 0.43
LMNA P02545 2/20 0.43
SMN1; SMN2 Q16637 1/20 0.43
CYP2A6 P11509 1/20 0.42
HSD17B10 Q99714 1/20 0.42
TTR P02766 2/20 0.41
POLB P06746 1/20 0.41
CASP6 P55212 1/20 0.41
ALDH1A3 P47895 1/20 0.39
VCAM1 P19320 1/20 0.39
STS P08842 1/20 0.38
MAPT P10636 1/20 0.37
HSP90AA1 P07900 1/20 0.37
F2 P00734 1/20 0.37
F10 P00742 1/20 0.37
DRD1 P21728 1/20 0.36
ADAMTS5 Q9UNA0 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1508467 0.88 HSD17B10 (0.50) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL8551788 0.85 F2 (0.50) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL894981 0.85 ALDH1A1 (0.61) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL31287758 0.85 ALDH1A1 (0.61) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL29984 0.85 ALDH1A1 (0.43) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL9107960 0.84 ALDH1A1 (0.40) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL3965437 0.82 FLT3 (0.41) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL14661923 0.81 POLB (0.50) ALDH1A1PARP10PARP3KDM4ELMNA
SCHEMBL8187061 0.81 TTR (0.64) ALDH1A1KDM4ELMNASMN1; SMN2CYP2A6
SCHEMBL9107585 0.81 KMT2A (0.47) ALDH1A1PARP10PARP3KDM4ELMNA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0696585-B1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMA CO LTD (JP) 1998-12-16 EP disclosed
US-5643931-A ANTIDIABETIC AGENTS YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) 1997-07-01 US disclosed
EP-0696585-A1 NOVEL BISOXADIAZOLIDINE DERIVATIVE YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) 1996-02-14 EP disclosed