Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 5/20 | 0.37 |
| ▸ | BRS3 | P32247 | 6/20 | 0.37 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.36 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.34 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547975 | 0.92 | KDM4E (0.39) | MMEAGTR1 | |
| SCHEMBL8549168 | 0.86 | MME (0.36) | MMEBRS3HCAR2AGTR1 | |
| SCHEMBL8550850 | 0.78 | KDM4E (0.39) | MMEAGTR1 | |
| SCHEMBL8550200 | 0.72 | AGTR1 (0.47) | AGTR1 | |
| SCHEMBL8550196 | 0.71 | LTB4R2 (0.53) | AGTR1 | |
| SCHEMBL8944228 | 0.71 | KDM4E (0.42) | AGTR1 | |
| SCHEMBL6605990 | 0.71 | BRS3 (0.39) | BRS3AGTR1 | |
| SCHEMBL443817 | 0.70 | MEN1 (0.43) | MMEBRS3HCAR2AGTR1 | |
| SCHEMBL8553680 | 0.70 | AGTR1 (0.37) | BRS3AGTR1 | |
| SCHEMBL6607829 | 0.69 | BRS3 (0.36) | BRS3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0588299-B1 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-01 | — | — | EP | disclosed |
| EP-0829479-A1 | Heterocyclic compounds and their use as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-03-18 | — | — | EP | disclosed |
| US-5500427-A | ANGIOTENSIN II ANTAGONISTS | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-03-19 | — | — | US | disclosed |
| EP-0588299-A2 | 1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-03-23 | — | — | EP | disclosed |