Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.38 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | CPS1 | P31327 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | APP | P05067 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8546757 | 0.80 | CYP3A4 (0.51) | KMT2ACYP2C19USP2CYP3A4MAPK1 | |
| SCHEMBL1924047 | 0.80 | CYP3A4 (0.50) | KMT2APOLBALDH1A1CYP1A2GAA | |
| SCHEMBL1162432 | 0.76 | KMT2A (0.46) | KMT2AALDH1A1CYP1A2GAA | |
| SCHEMBL1646977 | 0.75 | POLB (0.45) | PTGS2KMT2AGPR35TAAR1POLB | |
| SCHEMBL2382494 | 0.75 | CYP3A4 (0.53) | KMT2ATAAR1POLBCPS1ALDH1A1 | |
| SCHEMBL9241705 | 0.73 | TAAR1 (0.52) | TAAR1POLBCPS1ALDH1A1RAB9A | |
| SCHEMBL8017091 | 0.73 | CYP3A4 (0.55) | TAAR1POLBCPS1ALDH1A1GAA | |
| SCHEMBL1759022 | 0.73 | TAAR1 (0.42) | TAAR1CPS1ALDH1A1RAB9AHDAC1 | |
| SCHEMBL1162664 | 0.73 | CES2 (0.55) | KMT2AALDH1A1GAA | |
| SCHEMBL12248644 | 0.73 | GSK3B (0.50) | GPR35TAAR1CPS1ALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5821255-A | REGULATING THE SECRETION OF CORTICOTROPIN, BETA-ENDORPHIN OR PEPTIDES DERIVED FROM PROOPIOMELANOCORTIN | SANOFI (FR) | 1998-10-13 | — | — | US | disclosed |
| EP-0659747-B1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI SA (FR) | 1998-04-01 | — | — | EP | disclosed |
| US-5602132-A | USEFUL IN TREATMENT OF PATHOLOGIES INVOLVING CORTICOTROPIN RELEASING FACTOR | SANOFI (FR) | 1997-02-11 | — | — | US | disclosed |
| CN-1127252-A | Branched-amino-sbustituted thiazoles, processes for their preparation and the pharmaceutical compositions which contain them | SANOFI SA (FR) | 1996-07-24 | — | — | CN | disclosed |
| EP-0659747-A1 | Branched aminothiazole derivatives process for their preparation and pharmaceutical compositions containing them | SANOFI (FR) | 1995-06-28 | — | — | EP | disclosed |