SCHEMBL8550489

SCHEMBL8550489

CCCCc1nc(Cl)c(C=O)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OC(=O)c2ccccc2)cc1

nearest known ligand 0.67

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
AGTR2 P50052 2/20 0.65
GP6 Q9HCN6 1/20 0.55
AGTR1 P30556 1/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8553199 0.89 AGTR2 (0.62) AGTR2
SCHEMBL10476021 0.86 AGTR2 (0.65) AGTR2GP6AGTR1
SCHEMBL8550440 0.86 AGTR2 (0.64) AGTR2AGTR1
SCHEMBL8556377 0.85 AGTR2 (0.69) AGTR2AGTR1
SCHEMBL8555434 0.83 AGTR2 (0.60) AGTR2AGTR1
SCHEMBL1458467 0.83 AGTR2 (0.57) AGTR2AGTR1
SCHEMBL2276369 0.82 GP6 (0.61) AGTR2GP6AGTR1
SCHEMBL1459519 0.82 GP6 (0.65) AGTR2GP6AGTR1
SCHEMBL8550486 0.81 AGTR2 (0.56) AGTR2
SCHEMBL7608287 0.81 GP6 (0.59) AGTR2GP6AGTR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0503162-B1 Azole derivatives, process for their preparation and their application HOECHST AG (DE) 1998-04-22 EP disclosed
US-5482957-A Azole derivatives, process for their preparation and their use HOECHST AKTIENGESELLSCHAFT (DE) 1996-01-09 US disclosed
EP-0503162-A1 Azole derivatives, process for their preparation and their application HOECHST AKTIENGESELLSCHAFT (DE) 1992-09-16 EP disclosed