Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 14/20 | 0.56 |
| ▸ | EDNRA | P25101 | 12/20 | 0.56 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | ERN1 | O75460 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.34 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8594151 | 0.94 | EDNRB (0.63) | EDNRBEDNRAERN1HCRTR1HCRTR2 | |
| SCHEMBL8548806 | 0.93 | EDNRB (0.53) | EDNRBEDNRAHCRTR1HCRTR2 | |
| SCHEMBL8550830 | 0.91 | EDNRB (0.70) | EDNRBEDNRA | |
| SCHEMBL8550472 | 0.90 | EDNRB (0.56) | EDNRBEDNRAERN1HCRTR1HCRTR2 | |
| SCHEMBL8548007 | 0.89 | EDNRB (0.58) | EDNRBEDNRAERN1HCRTR1HCRTR2 | |
| SCHEMBL8547915 | 0.88 | EDNRB (0.46) | EDNRBEDNRASMN1; SMN2 | |
| SCHEMBL8547924 | 0.87 | EDNRB (0.56) | EDNRBEDNRAERN1HCRTR1HCRTR2 | |
| SCHEMBL8552955 | 0.86 | EDNRB (0.52) | EDNRBEDNRACSF1RERN1MEN1 | |
| SCHEMBL8551027 | 0.86 | EDNRB (0.53) | EDNRBEDNRACSF1R | |
| SCHEMBL8552822 | 0.86 | EDNRB (0.58) | EDNRBEDNRAERN1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |