Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.53 |
| ▸ | EDNRA | P25101 | 8/20 | 0.52 |
| ▸ | CSF1R | P07333 | 4/20 | 0.42 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | PLK1 | P53350 | 2/20 | 0.39 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.38 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8550887 | 0.93 | EDNRB (0.58) | EDNRBEDNRA | |
| SCHEMBL8551476 | 0.92 | EDNRB (0.48) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8552955 | 0.91 | EDNRB (0.52) | EDNRBEDNRACSF1RCTSLPLK1 | |
| SCHEMBL8550953 | 0.90 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8553797 | 0.90 | EDNRB (0.55) | EDNRBEDNRA | |
| SCHEMBL8551432 | 0.90 | EDNRB (0.64) | EDNRBEDNRA | |
| SCHEMBL8551023 | 0.89 | EDNRB (0.67) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8550898 | 0.89 | EDNRB (0.47) | EDNRBEDNRACTSLCTSBPLK1 | |
| SCHEMBL8549015 | 0.88 | EDNRB (0.50) | EDNRBEDNRACSF1RPLK1 | |
| SCHEMBL8548858 | 0.88 | EDNRB (0.45) | EDNRBEDNRACSF1RPLK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |