Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.52 |
| ▸ | EDNRA | P25101 | 8/20 | 0.52 |
| ▸ | CSF1R | P07333 | 3/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.37 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | PLK1 | P53350 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547974 | 0.93 | EDNRB (0.59) | EDNRBEDNRACSF1R | |
| SCHEMBL8551760 | 0.92 | EDNRB (0.49) | EDNRBEDNRACSF1RERN1CTSV | |
| SCHEMBL8551281 | 0.91 | EDNRB (0.49) | EDNRBEDNRACSF1RERN1 | |
| SCHEMBL8551027 | 0.91 | EDNRB (0.53) | EDNRBEDNRACSF1RCTSLPLK1 | |
| SCHEMBL8552951 | 0.89 | EDNRB (0.66) | EDNRBEDNRACSF1RERN1SRD5A1 | |
| SCHEMBL8551781 | 0.89 | EDNRB (0.52) | EDNRBEDNRA | |
| SCHEMBL8551949 | 0.88 | EDNRB (0.54) | EDNRBEDNRAMEN1KMT2ALMNA | |
| SCHEMBL8550833 | 0.86 | EDNRB (0.56) | EDNRBEDNRACSF1RERN1MEN1 | |
| SCHEMBL8550898 | 0.86 | EDNRB (0.47) | EDNRBEDNRACTSLSRD5A1SRD5A2 | |
| SCHEMBL8551761 | 0.86 | EDNRB (0.49) | EDNRBEDNRACSF1RMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |