Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | MMP3 | P08254 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 7/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | MMP2 | P08253 | 9/20 | 0.42 |
| ▸ | MMP9 | P14780 | 9/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | BRD3 | Q15059 | 1/20 | 0.37 |
| ▸ | BRDT | Q58F21 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554005 | 0.84 | BRD4 (0.48) | MMP8MMP3BRD4MMP2MMP9 | |
| SCHEMBL27550528 | 0.84 | MMP3 (0.46) | MMP8MMP3BRD4MMP2MMP9 | |
| SCHEMBL27491360 | 0.82 | MMP8 (0.69) | MMP8MMP3BRD4MMP2MMP9 | |
| SCHEMBL8551832 | 0.71 | MMP8 (0.65) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL8551231 | 0.69 | MMP3 (0.52) | MMP8MMP3MMP2MMP9 | |
| SCHEMBL8550568 | 0.69 | MMP3 (0.52) | MMP8MMP3BRD4MMP2MMP9 | |
| SCHEMBL8555925 | 0.69 | MMP8 (0.62) | MMP8MMP3MMP2MMP9MMP13 | |
| SCHEMBL20892490 | 0.68 | BRD4 (0.57) | MMP8MMP3BRD4BRD2BRD3 | |
| SCHEMBL8554743 | 0.68 | MMP3 (0.51) | MMP8MMP3BRD4MMP2MMP9 | |
| SCHEMBL7474462 | 0.67 | MMP8 (0.64) | MMP8MMP3MMP2MMP9MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1318406-C | New barbituric acid derivatives, processes for their prodn. and pharmaceutical agent contg. same | BOEHRINGER MANNHEIM GMBH (DE) | 2007-05-30 | — | — | CN | disclosed |
| EP-0869947-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997023465-A1 | NEW BARBITURIC ACID DERIVATIVES, PROCESSES FOR THEIR PRODUCTION AND PHARMACEUTICAL AGENTS CONTAINING THESE COMPOUNDS | BOEHRINGER MANNHEIM GMBH (DE) | 1997-07-03 | — | — | WO | disclosed |