SCHEMBL8551301

SCHEMBL8551301

O=C1OCC=C1c1ccc2ccccc2c1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GSTP1 P09211 1/20 0.48
NOTUM Q6P988 1/20 0.41
HDAC4 P56524 1/20 0.41
HDAC2 Q92769 1/20 0.41
HDAC8 Q9BY41 1/20 0.41
ESR1 P03372 1/20 0.40
ESR2 Q92731 1/20 0.40
ALOX5 P09917 1/20 0.39
TSHR P16473 1/20 0.39
CYP1A1 P04798 1/20 0.39
CYP1B1 Q16678 1/20 0.39
CYP1A2 P05177 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
CA1 P00915 1/20 0.39
CA2 P00918 1/20 0.39
CA9 Q16790 1/20 0.39
HSD17B1 P14061 1/20 0.38
HSD17B2 P37059 1/20 0.38
MIF P14174 1/20 0.38
CYP11B1 P15538 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30527823 1.00 GSTP1 (0.48) GSTP1NOTUMHDAC4HDAC2HDAC8
SCHEMBL13950154 0.84 GSTP1 (0.47) GSTP1NOTUMHDAC4HDAC2HDAC8
SCHEMBL979621 0.77 CFTR (0.43) SMN1; SMN2KDM4EMEN1ALDH1A1KMT2A
SCHEMBL3646655 0.74 GSTP1 (0.52) GSTP1NOTUMHDAC4HDAC2HDAC8
SCHEMBL7348557 0.74 ALOX5 (0.46) NOTUMALOX5SMN1; SMN2CYP11B1CYP11B2
SCHEMBL30527899 0.73 ALDH1A1 (0.41) TSHRSMN1; SMN2CA2CA9MEN1
SCHEMBL30527907 0.72 CYP1A2 (0.38) NOTUMTSHRCYP1A2CA1CA2
SCHEMBL30527856 0.72 KMT2A (0.31) KMT2A
SCHEMBL6602632 0.72 PTGS1 (0.43) NOTUMGABRA1GABRG2GABRB3ALDH1A1
SCHEMBL2167797 0.71 BACE1 (0.52) CYP1A2KDM4EMEN1ALDH1A1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0828724-A1 DIARYL-5-OXYGENATED-2-(5H)-FURANONES AS COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1998-03-18 EP claimed
WO-1996036623-A1 DIARYL-5-OXYGENATED-2-(5H)-FURANONES AS COX-2 INHIBITORS MERCK FROSST CANADA INC. (CA) 1996-11-21 WO claimed