Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.42 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | HPGD | P15428 | 3/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.42 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28471578 | 0.87 | KDM4E (0.44) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL29537275 | 0.82 | MAPT (0.49) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL580414 | 0.82 | MAPT (0.49) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL10662227 | 0.81 | SMN1; SMN2 (0.58) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL8554024 | 0.81 | ADORA2A (0.41) | SMN1; SMN2MAPTALDH1A1NPSR1KDM4E | |
| SCHEMBL7904933 | 0.76 | MAPT (0.63) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 | |
| SCHEMBL30170698 | 0.76 | AHR (0.41) | ALDH1A1HPGDCYP3A4HSD17B10MEN1 | |
| SCHEMBL8552255 | 0.75 | ADORA2A (0.44) | LMNASMN1; SMN2MAPTALDH1A1ATM | |
| SCHEMBL6585632 | 0.75 | PDE4A (0.60) | LMNASMN1; SMN2ALDH1A1NPSR1L3MBTL1 | |
| SCHEMBL4845442 | 0.75 | PDE4A (0.57) | LMNASMN1; SMN2MAPTALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0825187-A1 | Condensed pyridazinyl guanidines, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1998-02-25 | — | — | EP | disclosed |