Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 9/20 | 0.48 |
| ▸ | EDNRA | P25101 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547873 | 0.94 | EDNRB (0.46) | EDNRBEDNRAKDM4EHSD17B10 | |
| SCHEMBL8550986 | 0.88 | EDNRB (0.51) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8549255 | 0.85 | EDNRB (0.47) | EDNRBEDNRAMAPTALDH1A1HPGD | |
| SCHEMBL8548507 | 0.85 | EDNRB (0.54) | EDNRBEDNRAGAALMNASMN1; SMN2 | |
| SCHEMBL8553159 | 0.85 | EDNRB (0.54) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8552763 | 0.83 | EDNRB (0.47) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8551981 | 0.83 | EDNRB (0.42) | EDNRBEDNRAMAPTMAPK1TDP1 | |
| SCHEMBL8550887 | 0.83 | EDNRB (0.58) | EDNRBEDNRAKDM4EGAAMAPT | |
| SCHEMBL8547652 | 0.83 | EDNRB (0.64) | EDNRBEDNRAKDM4EHSD17B10GAA | |
| SCHEMBL8547597 | 0.82 | EDNRB (0.47) | EDNRBEDNRAKDM4EHSD17B10SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |