Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.46 |
| ▸ | EDNRA | P25101 | 7/20 | 0.44 |
| ▸ | CTSL | P07711 | 3/20 | 0.36 |
| ▸ | CTSV | O60911 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | CSF1R | P07333 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CTSB | P07858 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551478 | 0.94 | EDNRB (0.48) | EDNRBEDNRAKDM4EHSD17B10 | |
| SCHEMBL8549255 | 0.90 | EDNRB (0.47) | EDNRBEDNRATSHR | |
| SCHEMBL8551981 | 0.88 | EDNRB (0.42) | EDNRBEDNRAPDE4APDE4BPDE4C | |
| SCHEMBL8551760 | 0.87 | EDNRB (0.49) | EDNRBEDNRACTSLCTSVCSF1R | |
| SCHEMBL8551027 | 0.86 | EDNRB (0.53) | EDNRBEDNRACTSLCSF1RCTSB | |
| SCHEMBL8549201 | 0.85 | EDNRB (0.40) | EDNRBEDNRAKDM4EPDE4APDE4B | |
| SCHEMBL8548409 | 0.85 | EDNRB (0.41) | EDNRBEDNRAKDM4EHSD17B10 | |
| SCHEMBL8619717 | 0.84 | EDNRB (0.40) | EDNRBEDNRAKDM4EHSD17B10 | |
| SCHEMBL8549318 | 0.83 | EDNRB (0.43) | EDNRBEDNRAKDM4ECSF1R | |
| SCHEMBL8550986 | 0.82 | EDNRB (0.51) | EDNRBEDNRAKDM4EHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |