Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 8/20 | 0.42 |
| ▸ | EDNRA | P25101 | 5/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | PDE4A | P27815 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 1/20 | 0.33 |
| ▸ | GABRD | O14764 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.33 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.33 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549201 | 0.94 | EDNRB (0.40) | EDNRBEDNRATSHRTDP1PDE4A | |
| SCHEMBL8549255 | 0.94 | EDNRB (0.47) | EDNRBEDNRATSHRMAPTPLA2G2A | |
| SCHEMBL8548409 | 0.91 | EDNRB (0.41) | EDNRBEDNRAGABRA1GABRG2GABRB3 | |
| SCHEMBL8619717 | 0.90 | EDNRB (0.40) | EDNRBEDNRAPLA2G2AGABRA1GABRG2 | |
| SCHEMBL8549140 | 0.89 | EDNRB (0.48) | EDNRBEDNRATSHRTDP1PLA2G2A | |
| SCHEMBL8547873 | 0.88 | EDNRB (0.46) | EDNRBEDNRATSHRPDE4APDE4B | |
| SCHEMBL8551761 | 0.86 | EDNRB (0.49) | EDNRBEDNRATSHRTDP1MAPT | |
| SCHEMBL8551108 | 0.85 | EDNRB (0.50) | EDNRBEDNRAMAPTPLA2G2A | |
| SCHEMBL8551760 | 0.83 | EDNRB (0.49) | EDNRBEDNRA | |
| SCHEMBL8547935 | 0.83 | EDNRB (0.43) | EDNRBEDNRATSHRTDP1PLA2G2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |