Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 3/20 | 0.56 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.56 |
| ▸ | DRD4 | P21917 | 3/20 | 0.44 |
| ▸ | MGLL | Q99685 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | UBE2M | P61081 | 1/20 | 0.40 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8703019 | 0.88 | DRD2 (0.53) | DRD2SLC6A4KDM4EUBE2MDCUN1D1 | |
| SCHEMBL8702974 | 0.87 | DRD2 (0.53) | DRD2SLC6A4KDM4EUBE2MDCUN1D1 | |
| SCHEMBL8551607 | 0.83 | DRD2 (0.57) | DRD2SLC6A4UBE2MDCUN1D1CHRM4 | |
| SCHEMBL8551299 | 0.83 | DRD2 (0.52) | DRD2SLC6A4CNR1SMN1; SMN2KDM4E | |
| SCHEMBL7481598 | 0.82 | HTR1D (0.57) | DRD2 | |
| SCHEMBL8547948 | 0.82 | DRD2 (0.56) | DRD2SLC6A4DRD4DRD3 | |
| SCHEMBL8550541 | 0.81 | DRD2 (0.52) | DRD2SLC6A4SMN1; SMN2NPSR1MEN1 | |
| SCHEMBL8547062 | 0.81 | DRD2 (0.46) | DRD2SLC6A4UBE2MDCUN1D1 | |
| SCHEMBL8703834 | 0.81 | DRD2 (0.46) | DRD2SLC6A4UBE2MDCUN1D1CHRM3 | |
| SCHEMBL8704365 | 0.80 | DRD2 (0.42) | DRD2SLC6A4SMN1; SMN2KDM4EUBE2M |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5792763-A | MIGRAINES; ANALGESICS; DISEASES LINKED TO DECREASED NEUROTRANMISSION OF SEROTONIN IN MAMMALS | ELI LILLY AND COMPANY (US) | 1998-08-11 | — | — | US | disclosed |
| WO-1998015545-A1 | NEW SEROTONIN 5-HT1F AGONISTS | ELI LILLY AND COMPANY (US) | 1998-04-16 | — | — | WO | disclosed |
| EP-0835869-A2 | New serotonin 5-HT1F agonists | ELI LILLY AND COMPANY (US) | 1998-04-15 | — | — | EP | disclosed |