Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 12/20 | 0.40 |
| ▸ | KLK5 | Q9Y337 | 9/20 | 0.36 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.36 |
| ▸ | PRSS2 | P07478 | 3/20 | 0.36 |
| ▸ | PRSS3 | P35030 | 3/20 | 0.36 |
| ▸ | STS | P08842 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | THRB | P10828 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | ELANE | P08246 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8552602 | 0.72 | KDM4E (0.35) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL27579467 | 0.68 | KLK7 (0.46) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL27482569 | 0.68 | KLK7 (0.38) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL4706811 | 0.68 | KLK7 (0.38) | KLK7KLK5PRSS1PRSS2PRSS3 | |
| SCHEMBL21216203 | 0.66 | BACE1 (0.49) | KLK7STSGPR119 | |
| SCHEMBL31127354 | 0.66 | JAK2 (0.48) | KLK7STSGAATHRBSMN1; SMN2 | |
| SCHEMBL12239673 | 0.65 | KLK7 (0.59) | KLK7KLK5STSGAATHRB | |
| SCHEMBL15720471 | 0.65 | STS (0.47) | KLK7KLK5STSGAATHRB | |
| SCHEMBL18874691 | 0.65 | BACE1 (0.39) | KLK7KLK5STSELANEGPR119 | |
| SCHEMBL19840274 | 0.65 | BACE1 (0.39) | KLK7KLK5STSELANEGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |