Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KLK7 | P49862 | 7/20 | 0.59 |
| ▸ | KLK5 | Q9Y337 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CTSV | O60911 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 1/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | CTSC | P53634 | 1/20 | 0.41 |
| ▸ | CTSF | Q9UBX1 | 1/20 | 0.41 |
| ▸ | STS | P08842 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.39 |
| ▸ | PARP1 | P09874 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12239665 | 0.94 | KLK7 (0.65) | KLK7KLK5GAATHRBSMN1; SMN2 | |
| SCHEMBL21996511 | 0.89 | KLK7 (0.57) | KLK7KLK5CTSVCTSLCTSB | |
| SCHEMBL13495419 | 0.85 | KLK7 (0.54) | KLK7KLK5CTSVCTSLCTSB | |
| SCHEMBL2983392 | 0.84 | KLK7 (0.53) | KLK7KLK5STSHCRTR2KMT2A | |
| SCHEMBL2984486 | 0.83 | KLK7 (0.56) | KLK7CTSVCTSLCTSBCTSS | |
| SCHEMBL17674479 | 0.82 | KLK7 (0.63) | KLK7KLK5STSHCRTR2KMT2A | |
| SCHEMBL1150828 | 0.82 | KLK7 (0.55) | KLK7SMN1; SMN2CTSVCTSLCTSB | |
| SCHEMBL7698816 | 0.82 | KLK7 (0.55) | KLK7SMN1; SMN2CTSVCTSLCTSB | |
| SCHEMBL16732580 | 0.82 | KLK7 (0.55) | KLK7SMN1; SMN2CTSVCTSLCTSB | |
| SCHEMBL7511892 | 0.82 | KLK7 (0.55) | KLK7SMN1; SMN2CTSVCTSLCTSB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | US | disclosed |
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-11-03 | — | — | US | disclosed |
| US-9284297-B2 | Halofuginone analogs for inhibition of tRNA synthetases and uses thereof | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2016-03-15 | — | — | US | disclosed |
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | US | disclosed |
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) | 2011-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110263532-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | FUCA1, GARS1, AARS1 | KLK7 3004/4885KLK5 2391/4885GAA 193/4885 |
| US-20160317498-A1 | HALOFUGINONE ANALOGS FOR INHIBITION OF TRNA SYNTHETASES AND USES THEREOF | FUCA1, GARS1, AARS1 | KLK7 3004/4885KLK5 2391/4885GAA 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.