Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | KLK7 | P49862 | 5/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.32 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | NAMPT | P43490 | 1/20 | 0.31 |
| ▸ | KLK5 | Q9Y337 | 4/20 | 0.30 |
| ▸ | ATM | Q13315 | 2/20 | 0.30 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.30 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.30 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.30 |
| ▸ | CETP | P11597 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549243 | 0.79 | KDM4E (0.32) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL8551638 | 0.72 | KLK7 (0.40) | THRBKLK7SMN1; SMN2KLK5PRSS1 | |
| SCHEMBL22728246 | 0.70 | NR1H2 (0.42) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL16690469 | 0.69 | NR1H2 (0.46) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL3730644 | 0.68 | NR1H2 (0.45) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL16689228 | 0.68 | CHRM2 (0.41) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL8021097 | 0.68 | CHRM2 (0.42) | MAPTCHRM2CHRM1CHRM3GLA | |
| SCHEMBL14140977 | 0.68 | CHRM2 (0.40) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL352414 | 0.68 | CHRM2 (0.34) | KDM4EMAPTTHRBCHRM2CHRM1 | |
| SCHEMBL22096750 | 0.67 | CHRM2 (0.46) | KDM4EMAPTTHRBCHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0824523-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. Searle & Co. (US) | 1998-02-25 | — | — | EP | disclosed |
| WO-1996035677-A1 | NITRIC OXIDE SYNTHASE INHIBITORS DERIVED FROM CYCLIC AMIDINES | G.D. SEARLE & CO. (US) | 1996-11-14 | — | — | WO | disclosed |