Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A | P35498 | 1/20 | 0.55 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.55 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.53 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.53 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | CCR3 | P51677 | 1/20 | 0.48 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8551715 | 0.99 | KMT2A (0.57) | SCN1ASCN2ASCN3AKMT2ASIGMAR1 | |
| SCHEMBL8551850 | 0.90 | SIGMAR1 (0.60) | KMT2ASIGMAR1CCR3 | |
| Hydrochloric Acid SCHEMBL8550732 | 0.89 | KMT2A (0.60) | KMT2ASIGMAR1CCR3 | |
| SCHEMBL8551160 | 0.87 | SCN1A (0.61) | SCN1ASCN2ASCN3AHTR2A | |
| SCHEMBL8551873 | 0.87 | SCN1A (0.55) | SCN1ASCN2ASCN3AKMT2A | |
| SCHEMBL8550697 | 0.87 | SCN1A (0.55) | SCN1ASCN2ASCN3AKMT2ASIGMAR1 | |
| SCHEMBL8552204 | 0.87 | SCN1A (0.55) | SCN1ASCN2ASCN3AKMT2ASIGMAR1 | |
| Hydrochloric Acid SCHEMBL8554961 | 0.86 | SCN1A (0.60) | SCN1ASCN2ASCN3AHTR2A | |
| SCHEMBL8550662 | 0.86 | SCN1A (0.63) | SCN1ASCN2ASCN3AKMT2APOLB | |
| Hydrochloric Acid SCHEMBL8551263 | 0.86 | SCN1A (0.54) | SCN1ASCN2ASCN3AKMT2ASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |