Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 11/20 | 0.46 |
| ▸ | EDNRA | P25101 | 3/20 | 0.46 |
| ▸ | PLA2G2A | P14555 | 7/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551944 | 0.91 | EDNRB (0.46) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8549137 | 0.89 | EDNRB (0.58) | EDNRBEDNRAPLA2G2AAGTR1AGTR2 | |
| SCHEMBL8551781 | 0.85 | EDNRB (0.52) | EDNRBEDNRA | |
| SCHEMBL8547683 | 0.84 | EDNRB (0.41) | EDNRBEDNRAPLA2G2AMAPTAGTR1 | |
| SCHEMBL8548217 | 0.82 | EDNRB (0.51) | EDNRBEDNRAMAPT | |
| SCHEMBL8550898 | 0.82 | EDNRB (0.47) | EDNRBEDNRA | |
| SCHEMBL8551941 | 0.80 | EDNRB (0.58) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8552487 | 0.80 | EDNRB (0.44) | EDNRBEDNRAMAPT | |
| SCHEMBL8550953 | 0.80 | EDNRB (0.64) | EDNRBEDNRAPLA2G2A | |
| SCHEMBL8551492 | 0.78 | ALOX5 (0.37) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |