Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 19/20 | 0.59 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8547366 | 0.93 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9221360 | 0.91 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL9221371 | 0.88 | ALOX5 (0.68) | ALOX5 | |
| SCHEMBL7814703 | 0.86 | ALOX5 (0.47) | ALOX5PTGS1PTGS2 | |
| SCHEMBL12707332 | 0.86 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL7802551 | 0.85 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL8781473 | 0.84 | ALOX5 (0.46) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9217663 | 0.84 | ALOX5 (0.61) | ALOX5 | |
| SCHEMBL9224526 | 0.84 | ALOX5 (0.47) | ALOX5 | |
| SCHEMBL9029002 | 0.84 | ALOX5 (0.70) | ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 32 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752990-B1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5665749-A | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0752990-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| CN-1031266-C | Process for preparation of heterocycle ether derivatives | ZENECA LTD (GB) | 1996-03-13 | — | — | CN | disclosed |
| EP-0462831-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1996-02-28 | — | — | EP | disclosed |
| US-5462953-A | Benzoxazolyl derivatives useful as 5-lipoxygenase inhibitors | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1995-10-31 | — | — | US | disclosed |
| EP-0462813-B1 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LTD (GB) | 1995-10-25 | — | — | EP | disclosed |
| EP-0462830-B1 | Cyclic ether derivatives | ZENECA LTD (GB) | 1995-10-18 | — | — | EP | disclosed |
| WO-1995026346-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1995-10-05 | — | — | WO | disclosed |
| EP-0466452-B1 | Thioxo heterocycles and their pharmaceutical use | ZENECA LTD (GB) | 1995-09-20 | — | — | EP | disclosed |
| US-5217969-A | Antiinflammatory, antiulcer agent | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-06-08 | — | — | US | disclosed |
| US-5179115-A | Antiinflammatory agents, antiallergens | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1993-01-12 | — | — | US | disclosed |
| US-5134148-A | Heterocycles for use as inhibitors of leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-07-28 | — | — | US | disclosed |
| US-5098930-A | Inhibitors of lipoxygenase for treatment of diseases mediated with leukotrienes | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-03-24 | — | — | US | disclosed |
| EP-0466452-A2 | Thioxo heterocycles and their pharmaceutical use | ZENECA LIMITED (GB) | 1992-01-15 | — | — | EP | disclosed |
| EP-0462831-A2 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462830-A2 | Cyclic ether derivatives | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
| EP-0462813-A2 | Bicyclic pyran derivatives and their use as inhibitors of 5-lipoxygenase | ZENECA LIMITED (GB) | 1991-12-27 | — | — | EP | disclosed |
| CN-1046903-A | Process for preparing heterocyclic ether derivatives | ICI PLC (GB) | 1990-11-14 | — | — | CN | disclosed |
| EP-0385662-A2 | Heterocycles with inhibitory activity of 5-lipoxygenase | ZENECA LIMITED (GB) | 1990-09-05 | — | — | EP | disclosed |