Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 20/20 | 0.52 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.43 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551875 | 0.93 | ALOX5 (0.59) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9221360 | 0.83 | ALOX5 (0.53) | ALOX5 | |
| SCHEMBL8550340 | 0.82 | ALOX5 (0.61) | ALOX5PTGS1PTGS2 | |
| SCHEMBL7814703 | 0.82 | ALOX5 (0.47) | ALOX5PTGS1PTGS2 | |
| SCHEMBL12707332 | 0.81 | ALOX5 (0.52) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9221371 | 0.81 | ALOX5 (0.68) | ALOX5 | |
| SCHEMBL7802551 | 0.81 | ALOX5 (0.56) | ALOX5 | |
| SCHEMBL9212748 | 0.81 | ALOX5 (0.49) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9212541 | 0.81 | ALOX5 (0.49) | ALOX5PTGS1PTGS2 | |
| SCHEMBL9212534 | 0.81 | ALOX5 (0.49) | ALOX5PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0752990-B1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER (US) | 1998-08-05 | — | — | EP | disclosed |
| US-5665749-A | Benzisothiazoles derivatives as inhibitors of 5-lipoxygenase biosynthesis | PFIZER INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0752990-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1997-01-15 | — | — | EP | disclosed |
| WO-1995026346-A1 | BENZISOTHIAZOLES DERIVATIVES AS INHIBITORS OF 5-LIPOXYGENASE BIOSYNTHESIS | PFIZER INC. (US) | 1995-10-05 | — | — | WO | disclosed |