Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.62 |
| ▸ | BCHE | P06276 | 2/20 | 0.58 |
| ▸ | PTPRF | P10586 | 1/20 | 0.53 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.53 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.53 |
| ▸ | SCN1A | P35498 | 2/20 | 0.53 |
| ▸ | SCN2A | Q99250 | 2/20 | 0.53 |
| ▸ | SCN3A | Q9NY46 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8552833 | 0.99 | SIGMAR1 (0.61) | SIGMAR1BCHEPTPRFPTPN2PTPN1 | |
| SCHEMBL8551865 | 0.86 | BCHE (0.60) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| SCHEMBL8552461 | 0.85 | BCHE (0.58) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| SCHEMBL8551180 | 0.85 | BCHE (0.58) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| SCHEMBL8550391 | 0.85 | POLB (0.62) | BCHESCN1ASCN2ASCN3AKDM4E | |
| SCHEMBL8551876 | 0.85 | BCHE (0.58) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL8551643 | 0.85 | BCHE (0.58) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL8553248 | 0.84 | BCHE (0.57) | SIGMAR1BCHESCN1ASCN2ASCN3A | |
| Hydrochloric Acid SCHEMBL8556314 | 0.84 | POLB (0.61) | BCHESCN1ASCN2ASCN3AMEN1 | |
| Hydrochloric Acid SCHEMBL8551440 | 0.84 | BCHE (0.57) | SIGMAR1BCHESCN1ASCN2ASCN3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | claimed |
| CN-1084329-C | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 2002-05-08 | — | — | CN | disclosed |
| EP-0871613-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1998-10-21 | — | — | EP | disclosed |
| CN-1183768-A | Benzyl piepridine derivs as pharmaceutical agents | HOFFMANN LA ROCHE (CH) | 1998-06-03 | — | — | CN | disclosed |
| US-5753679-A | SCIZOPHRENIA | HOFFMANN-LA ROCHE INC. (US) | 1998-05-19 | — | — | US | disclosed |
| WO-1996035666-A1 | BENZYL PIPERIDINE DERIVATIVES AS PHARMACEUTICAL AGENTS | F.HOFFMANN-LA ROCHE AG (CH) | 1996-11-14 | — | — | WO | disclosed |