Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD5 | Q86SK9 | 7/20 | 0.62 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | THRB | P10828 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8657527 | 0.85 | SCD5 (0.53) | SCD5MAPTTP53THRBLMNA | |
| SCHEMBL20676587 | 0.82 | SCD5 (0.48) | SCD5MAPTTHRBHTT | |
| SCHEMBL13940704 | 0.81 | NPC1 (0.52) | SCD5NPC1RAB9AMAPTTP53 | |
| SCHEMBL20676584 | 0.79 | SCD5 (0.45) | SCD5MAPTTHRBHTT | |
| SCHEMBL3068961 | 0.77 | SCD5 (0.56) | SCD5MAPTTP53THRBLMNA | |
| SCHEMBL21536288 | 0.77 | SCD5 (1.00) | SCD5NPC1RAB9AMAPTTP53 | |
| SCHEMBL20676330 | 0.76 | GPR119 (0.49) | SCD5HTT | |
| SCHEMBL12580569 | 0.76 | SCD5 (0.59) | SCD5MAPTTP53LMNAMMP13 | |
| SCHEMBL30182200 | 0.76 | MAPT (0.49) | NPC1RAB9AMAPTTHRBHTT | |
| SCHEMBL20676655 | 0.75 | GPR119 (0.43) | SCD5MAPTTHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0822814-A4 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO INC (US) | 1998-12-09 | — | — | EP | disclosed |
| EP-0822814-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | Merck & Co., Inc. (US) | 1998-02-11 | — | — | EP | disclosed |
| US-5668148-A | BENIGN PROSTATIC HYPERTROPHY | MERCK & CO., INC. (US) | 1997-09-16 | — | — | US | disclosed |
| WO-1996032938-A1 | ALPHA 1a ADRENERGIC RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1996-10-24 | — | — | WO | disclosed |