Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 5/20 | 0.41 |
| ▸ | EDNRA | P25101 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.33 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.33 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.30 |
| ▸ | TSPO | P30536 | 1/20 | 0.30 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.30 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551085 | 0.92 | EDNRB (0.45) | EDNRBEDNRA | |
| SCHEMBL8548125 | 0.91 | EDNRB (0.45) | EDNRBEDNRAAGTR1AGTR2 | |
| SCHEMBL8551990 | 0.90 | EDNRB (0.51) | EDNRBEDNRAAGTR1AGTR2 | |
| SCHEMBL8553569 | 0.88 | EDNRB (0.54) | EDNRBEDNRA | |
| SCHEMBL8550816 | 0.88 | EDNRB (0.43) | EDNRBEDNRAAGTR1AGTR2PTGES2 | |
| SCHEMBL8547944 | 0.87 | EDNRB (0.44) | EDNRBEDNRAAGTR2 | |
| SCHEMBL8624245 | 0.87 | EDNRB (0.43) | EDNRBEDNRAAGTR1AGTR2 | |
| SCHEMBL8548902 | 0.85 | EDNRB (0.43) | EDNRBEDNRA | |
| SCHEMBL8550374 | 0.85 | EDNRB (0.43) | EDNRBEDNRAAGTR1AGTR2 | |
| SCHEMBL8550380 | 0.83 | EDNRB (0.41) | EDNRBEDNRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0863898-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK PATENT GmbH (DE) | 1998-09-16 | — | — | EP | disclosed |
| WO-1997019077-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1997-05-29 | — | — | WO | disclosed |