Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 19/20 | 0.48 |
| ▸ | WNT1 | P04628 | 9/20 | 0.48 |
| ▸ | CLK2 | P49760 | 3/20 | 0.48 |
| ▸ | CLK3 | P49761 | 3/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.48 |
| ▸ | PARP1 | P09874 | 1/20 | 0.46 |
| ▸ | DHODH | Q02127 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL6587886 | 1.00 | DYRK1A (0.48) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6584434 | 0.91 | DYRK1A (0.50) | DYRK1AWNT1CLK2CLK3GSK3B | |
| Fumaric Acid SCHEMBL6584532 | 0.85 | DYRK1A (0.50) | DYRK1AWNT1CLK2CLK3GSK3B | |
| Fumaric Acid SCHEMBL6592880 | 0.83 | DRD2 (0.52) | DYRK1AWNT1CLK2CLK3GSK3B | |
| Fumaric Acid SCHEMBL6592877 | 0.83 | DRD2 (0.52) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6587883 | 0.80 | DYRK1A (0.48) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6584206 | 0.74 | DRD2 (0.56) | DYRK1AWNT1CLK2CLK3GSK3B | |
| SCHEMBL6584525 | 0.74 | DYRK1A (0.50) | DYRK1AWNT1CLK2CLK3GSK3B | |
| Fumaric Acid SCHEMBL6971268 | 0.73 | KDM4E (0.43) | — | |
| Fumaric Acid SCHEMBL6971255 | 0.73 | KDM4E (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0871615-A1 | SUBSTITUTED PYRIDINE DERIVATIVES, THEIR PREPARATION AND THEIR USE AS MODULATORS OF ACETYLCHOLINE RECEPTORS | SIBIA NEUROSCIENCES, INC. (US) | 1998-10-21 | — | — | EP | disclosed |